78221 ZIP Code, San Antonio, TX

78221 is a ZIP code in San Antonio, Texas in Bexar County. It covers 36 square miles of land, centered about 8.7 miles south of downtown San Antonio. The closest ZIP codes are 78214, 78224 and 78235. 42,178 people live here in 13,264 households. At about 1,162 people per square mile it has suburban density, and most homes are owner-occupied (70%). Median household income is $63,811, below the Texas median of $78,476; 43% of households have children under 18.

Quick facts

Key figures

MeasureValue
Residents42,178
Households13,264
Median household income$63,811
Income per person$24,423
Median age34
Homeowners70.2%
Median home value$171,200
Median rent$1,228
Bachelor's degree or higher12.2%
Average commute (minutes)26.1
Households with kids under 1843.0%
Moved in the past year11.2%
Below the poverty line17.3%
Broadband internet85.2%
Speak a non-English language at home52.0%

Household income

% of householdsValue
<$10K8.2%
$10–15K3.6%
$15–25K8.6%
$25–35K8.4%
$35–50K11.7%
$50–75K16.9%
$75–100K15.1%
$100–150K21.0%
$150–200K4.1%
$200K+2.4%

Age

% of all residentsValue
<1012.6%
10–1917.1%
20–247.7%
25–3414.0%
35–4412.8%
45–5413.9%
55–6410.0%
65–746.9%
75+5.0%

Tenure

% of housing unitsValue
Owned, with mortgage32.3%
Owned outright29.4%
Rented25.9%
Vacant12.3%

Type of building

% of housing unitsValue
Detached house78.8%
Townhome1.1%
2–4 units4.8%
5–19 units7.1%
20+ units3.9%
Mobile / other4.4%

Businesses in 78221

513 business establishments with 27,803 employees (ZIP Codes Business Patterns 2023).

EDDM carrier routes

78221 has 17 USPS carrier routes with 16,162 residential and 930 business mailboxes. Open the EDDM route map.

Carrier routes in 78221

78221 has 17 USPS carrier routes (12 city (C), 5 rural (R)) with 16,162 residential and 930 business mailboxes. Routes range from 552 homes (C080) to 1,315 homes (R262); the median route has 953 homes. The Census counted 13,264 households in 78221 (2020–2024 average); USPS counts current mailboxes, including new and vacant homes.

Homes per routeRoutes
1–2490
250–4990
500–7493
750–9997
1,000–1,4997
1,500+0

Best routes in 78221 for…

Highest income

For bigger-ticket offers: remodeling, pools, financial planning, private schools.

  1. Route R162 — Est. median household income $91,486, 953 homes
  2. Route C087 — Est. median household income $90,940, 1,068 homes
  3. Route R262 — Est. median household income $90,386, 1,315 homes
  4. Route R013 — Est. median household income $77,413, 1,217 homes
  5. Route C072 — Est. median household income $75,165, 951 homes

Select these 5 routes on the route map

Often mailed by: Home services EDDM, Real estate EDDM postcards, Landscaping and lawn care mailers

Most families with kids

For tutoring, youth sports, pediatric dental, child care and family dining.

  1. Route R162 — Est. families with children under 18 54.9%, 953 homes
  2. Route R262 — Est. families with children under 18 54.5%, 1,315 homes
  3. Route C078 — Est. families with children under 18 54.2%, 942 homes
  4. Route C075 — Est. families with children under 18 47.7%, 1,131 homes
  5. Route C087 — Est. families with children under 18 43.8%, 1,068 homes

Select these 5 routes on the route map

Often mailed by: Dental practice EDDM, Healthcare and clinic mailers

Most homeowners

Owners decide on roofs, HVAC, lawns, solar and insurance; renters usually can't.

  1. Route C087 — Est. owner-occupied homes 89.9%, 1,068 homes
  2. Route C072 — Est. owner-occupied homes 83.4%, 951 homes
  3. Route R013 — Est. owner-occupied homes 80.8%, 1,217 homes
  4. Route R329 — Est. owner-occupied homes 75.2%, 1,280 homes
  5. Route R162 — Est. owner-occupied homes 75.2%, 953 homes

Select these 5 routes on the route map

Often mailed by: Roofing direct mail, HVAC postcards

Most new movers

New residents are still choosing a dentist, a gym and a lawn service.

  1. Route R162 — Est. residents who moved in the past year 19.4%, 953 homes
  2. Route R262 — Est. residents who moved in the past year 19.3%, 1,315 homes
  3. Route R031 — Est. residents who moved in the past year 19.2%, 978 homes
  4. Route C077 — Est. residents who moved in the past year 15.5%, 586 homes
  5. Route C072 — Est. residents who moved in the past year 14.4%, 951 homes

Select these 5 routes on the route map

Often mailed by: Restaurant EDDM menus and offers, Gym and fitness mailers

Newest homes

Newer subdivisions: landscaping, window treatments, fencing, security, home warranties.

  1. Route R162 — Est. homes built 2010 or later 72.6%, 953 homes
  2. Route R262 — Est. homes built 2010 or later 70.9%, 1,315 homes
  3. Route R013 — Est. homes built 2010 or later 33.0%, 1,217 homes
  4. Route R329 — Est. homes built 2010 or later 24.6%, 1,280 homes
  5. Route R031 — Est. homes built 2010 or later 23.5%, 978 homes

Select these 5 routes on the route map

Most businesses

For B2B offers: office supplies, cleaning, IT, catering and commercial services.

  1. Route C068 — USPS business mailboxes 199, 624 homes
  2. Route C080 — USPS business mailboxes 189, 552 homes
  3. Route C082 — USPS business mailboxes 98, 817 homes
  4. Route C074 — USPS business mailboxes 85, 811 homes
  5. Route C073 — USPS business mailboxes 74, 1,138 homes

Select these 5 routes on the route map

Every carrier route in 78221

RouteTypeHomesBusinessesEst. median incomeEst. ownersEst. families with kidsEst. moved in past year
C068City624199$40,70369.8%32.8%7.3%
C071City1,00955$55,99354.6%37.2%13.8%
C072City9517$75,16583.4%32.8%14.4%
C073City1,13874$62,63465.8%32.9%7.0%
C074City81185$45,58353.6%32.2%6.0%
C075City1,13149$65,03771.0%47.7%12.9%
C076City79054$45,39356.9%42.9%5.9%
C077City5861$63,40569.1%41.9%15.5%
C078City94223$42,54459.6%54.2%6.7%
C080City552189$53,47665.1%28.4%6.6%
C082City81798$54,59364.0%30.3%7.5%
C087City1,06811$90,94089.9%43.8%12.6%
R013Rural1,21720$77,41380.8%42.0%10.7%
R031Rural97814$60,21655.8%30.1%19.2%
R162Rural9532$91,48675.2%54.9%19.4%
R262Rural1,3151$90,38674.5%54.5%19.3%
R329Rural1,28048$63,87575.2%37.6%13.6%

Income, owners, families and movers are estimates for each route (how we estimate them); mailbox counts are current USPS figures. Open 78221 on the EDDM route map.

How route demographics are estimated

Mailbox counts come from USPS; demographics are estimates

The number of homes and businesses on each carrier route is the current USPS EDDM count. The Census Bureau does not publish figures for carrier routes, so income, homeownership, ages, families, movers and housing age on a route are EDDM2GO estimates built from Census block groups (neighborhood areas of roughly 600 to 3,000 people).

How a route gets its figures: the block-group length-share method

We trace each route's streets every 25 meters and record which block group each stretch falls in. The route's homes are spread along its streets in proportion to length, so a route with 60% of its street length in one block group is assumed to have 60% of its homes there. Each block group then contributes its Census counts in proportion to the share of its housing units that sit on the route (capped at the whole block group). Medians are recalculated from the combined income, home-value and age brackets, the way the Census Bureau computes them, not averaged.

Margins of error

Census survey figures carry a margin of error at 90% confidence; we carry it through the calculation and show it as ±. Our margins treat the route-to-block-group split as exact, so the real uncertainty is larger. Routes with fewer than 100 estimated households, large margins, or streets we could not place are flagged.

Different years

USPS mailbox counts are current. Census figures are 5-year averages for 2020–2024, so a new subdivision may have more homes on the route today than the Census counted. Use the route figures to compare routes with each other, not as an exact head count.

Why some routes show identical figures

Two routes that run through the same block group get the same percentages and medians, because the Census publishes one set of figures for the whole block group. Their mailbox counts still differ, and those are exact.

Route and mailbox counts: USPS EDDM route data. Route demographics: EDDM2GO estimates from U.S. Census Bureau American Community Survey 5-year block-group data (2020–2024) and 2024 cartographic block-group boundaries. This product uses the Census Bureau Data API but is not endorsed or certified by the Census Bureau.

Nearby ZIP codes

Areas that include 78221

Where it ranks

Mail every home in 78221

Route counts on this page price as Full Service 6.5 × 9 postcards: we print, bundle by carrier route and hand the mailing to USPS. Prefer to take it to the Post Office yourself? Print only costs less and you pay postage at drop-off.

San Antonio EDDM mailing

EDDM guides

ZIP code statistics describe the Census ZIP Code Tabulation Area (ZCTA) 78221, which approximates the USPS ZIP code area. Census figures: American Community Survey 5-year estimates, 2020–2024.

Frequently asked questions

What city is 78221 in?
78221 is a San Antonio, TX mailing address. By land area, 47% lies inside San Antonio; the rest is outside any Census-defined city or community.
What county is 78221 in?
78221 is in Bexar County.
What is the population of 78221?
About 42,178 people (±3,119), according to the Census Bureau's American Community Survey 5-year estimates for 2020–2024. The 2020 Census counted 39,779.
What is the median household income in 78221?
$63,811 (±$6,035), compared with $78,476 for Texas as a whole. Half the households in the ZIP code earn more and half earn less.
How many carrier routes and mailboxes are in 78221?
17 USPS carrier routes with 16,162 residential and 930 business mailboxes (17,092 in all), from the route data stored by EDDM2GO. An EDDM mailing can target any combination of these routes.
What ZIP codes are near 78221?
The closest, measured center to center: 78214 (3.6 mi, San Antonio), 78224 (3.9 mi, San Antonio), 78235 (4.1 mi, San Antonio), 78223 (5.8 mi, San Antonio), 78211 (6.1 mi, San Antonio) and 78225 (6.7 mi, San Antonio).

This product uses the Census Bureau Data API but is not endorsed or certified by the Census Bureau.